PT021 The effects of Cilostazol on the ion Channels in rat right ventricular myocyte

Abstract

Introduction: Chest pain is a common presentation in primary care. Although coronary artery disease is an infrequent etiology in this setting, it should be ruled out. In this context, the electrocardiogram (ECG) is very useful to assess patients with chest pain. Objectives: To assess the prevalence of ECG abnormalities in primary care patients with chest pain. Methods: This is an observational retrospective study. All ECGs performed by the Telehealth Network of Minas Gerais, a Brazilian public telehealth service, from January to December 2011, were analyzed. This service attends 660 cities in the state of Minas Gerais. The prevalence of ECG abnormalities was assessed. Results: During the study period, 197,101 ECGs were performed in patients with chest pain (mean age 50 19 years, 59.4% women). Hypertension was the most frequent comorbidity (26.8%). Family history of coronary artery disease was reported in 13.1%, smoking in 6.3% and diabetes in 4.6%. Regarding the ECGs, 61.7% had no abnormalities. The prevalence of abnormalities suggestive of ischemia was 4.4%: 2.5% poor R wave progression, 1.5% abnormalities suggestive of acute ischemia; 0.4% pathological Q waves. First degree atrioventricular block as observed in 1.8%, left bundle branch block in 1.6%, right bundle branch block in 2.8%, atrial fibrillation 1.7%, left ventricular or atrial hypertrophy in 6.5%, premature beats in 4.2% and nonspecific repolarization abnormalities in 17.4%. Although the percentage of patients with abnormalities suggestive of acute ischemia is low, primary care physicians should have in mind that a normal ECG does not rule out coronary artery disease, and a careful clinical assessment should be performed in all patients. Conclusion: In this study in a large sample of primary care patients with chest pain, the prevalence of exams with no abnormalities is higher than 50%, and a minority of patients has abnormalities suggestive of myocardial ischemia. Disclosure of Interest: None Declared