Abstract
(1) Background: In this work, we investigated the application of a natural superdisintegrant, psyllium (Plantago ovata Forsk) husk powder, for the manufacture of orodispersible meloxicam tablets. Meloxicam was chosen as a model compound for the study. (2) Methods: The tablets were prepared using different concentrations of psyllium husk by direct compression. Bulk density, tapped density, hardness, friability, in vitro disintegration, and dissolution time tests were used to assess the quality of the formulations. (3) Results: Psyllium husk powder significantly increased the dissolution rate of meloxicam. The formulation containing 16 mg of psyllium husk powder showed the lowest wetting time, the highest water absorption ratio, and the lowest disintegration time compared to the control and to the other formulations. These effects may be attributed to the rapid uptake of water due to the vigorous swelling ability of psyllium husk powder. (4) Conclusions: The powder could be recommended as an effective natural superdisintegrant for orodispersible formulations.
Highlights
Plantago ovata belongs to the family of Plantaginaceae [1]
Since natural disintegrants are preferred due to their non-toxicity [16]. They generally reduce in vitro dissolution time and increase the water absorption ratio [25], in this study we investigated the application of the natural disintegrant psyllium (Plantago ovata Forsk) husk powder for the manufacture of orodispersible meloxicam tablets
The dissolution rate of meloxicam was significantly enhanced in the orodispersible tablets prepared with psyllium (Plantago ovata Forsk) husk powder as a superdisintegrant
Summary
Plantago ovata belongs to the family of Plantaginaceae [1]. The seeds and psyllium husk of this plant are valuable sources of fibers and mucilage. They generally reduce in vitro dissolution time and increase the water absorption ratio [25], in this study we investigated the application of the natural disintegrant psyllium (Plantago ovata Forsk) husk powder for the manufacture of orodispersible meloxicam tablets. Psyllium husk polysaccharide isolated by the solvent precipitation method was successfully used as superdisintegrant for valsartan orodispersible formulation [26], demonstrating an in vitro disintegration time of 20.34 s, a wetting time of 12.60 s, a water absorption ratio of 143.37, and a cumulative drug release of ~75% after. Psyllium husk mucilage was used for prochlorperazine maleate fast disintegration tablets, demonstrating an in vitro dispersion time of 8 s, a wetting time of 11 s, and a water absorption ratio of 86%; a faster drug release (t50% 3.3 min) was reported for the 8% psyllium husk mucilage formulation [6]. Bulk density, tapped density, hardness, friability, in vitro disintegration, and dissolution time tests were used to assess the quality of the formulations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
