Abstract
Treatment-resistant depression (TRD) describes those who have not responded to at least two other treatments for depression. These individuals require additional support to reach remission of their symptoms. Psychotherapy modalities can be a way to augment treatment of depression without additional medications. This article discusses the use of interpersonal therapy, dialectical behavioral therapy, radically open dialectical behavioral therapy, cognitive-behavioral therapy, and intensive short-term dynamic psychotherapy. All of these therapies can achieve increased rates of remission and improvement of depressive symptoms when compared to treatment as usual. No significant adverse events have noted in the studies that have looked at these various treatments. Areas for future research include delineation of which specific modalities are best suited to addressing the needs of individual patients. As part of a comprehensive treatment plan, psychotherapy should be considered when addressing TRD. [ Psychiatr Ann . 2024;54(6):e182–e185.]
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