Abstract

In addition to the organ pathology following organ transplantation that is described in the article, allotransplantation may be associated with a multitude of psychological stress reactions and disorders. Physically severely ill patients associate their organ transplantation procedure with their hopes for health and wellbeing. For many patients, the need for lifelong drug treatment, the possibility of organ failure, the damage to other organ systems as a result of immunosuppression, or the associated risk of developing cancer are not compatible with a life free from fear and anxiety and a sufficiently high quality of life. In order to be able to experience the donor organ and the associated lifestyle changes not as a threat but a life enhancing event, patients often need to completely deny the existence of such risks in their everyday lives. The possible result includes problems with adherence, meaning: the ability and willingness of a patient to participate actively in the implementation of a therapeutic regimen. This entails, for example, the reliable administration of the prescribed immunosuppressive drugs. Non-adherence has been shown to be associated with an increased risk for acute rejection, infections, and chronic rejection of the transplanted organ (1, 2). After a transplantation procedure, the fear of transplant rejection and failure is a stressor that can trigger anxiety related and depressive adjustment disorders after the operation. Equally, psychological acceptance of the donor organ can present a formidable difficulty and may manifest as depressive symptoms or identity disorders. Recent studies have therefore pointed out a need for more psychosocial aftercare in transplant patients (3).

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