Psychosis in a multiple sclerosis patient and antipsychotic treatment

Abstract

We present a case of a 35 years old male affected by mul-tiple sclerosis in the last 6 years under treatment withinterferons. One year after the diagnosis of the demyeli-nating disease, the patient developed psychiatric manifes-tations and he referred to a psychiatric clinic where wasformulated the diagnosis of psychosis. There was no fam-ily or personal history of psychiatric disease or psycho-tropic medication/substance use. The patient initially hasbeen treated with risperidone and with an exception of arelapse, because of non-compliance, has been almost sta-ble for about 5 years. At the age of 35 years he has beenrecovered to our clinic due to a severe exacerbation of thepsychosis which persistent symptoms leaded to a changeof the antipsychotic treatment. Initially he began onsertindole for one month with poor response. Thus he haschanged treatment and the following administration ofclozapine had as a result the remission of the symptoms.