Abstract
BackgroundThe modified polycystic ovary syndrome health-related quality-of-life questionnaire (MPCOSQ) is a 30-item instrument measuring quality-of-life in English-speaking patients with polycystic ovary syndrome (PCOS). We aimed to: 1) cross-culturally adapt the MPCOSQ into Chinese, and 2) assess the validity and reliability of the Chinese version of the MPCOSQ (Chi-MPCOSQ).MethodsThe MPCOSQ was translated using the forward-backward method, and its validity and reliability were assessed among 283 Chinese patients with PCOS. Internal consistency reliability and test-retest reliability were assessed by Cronbach’s α and intra-correlation coefficient (ICC), respectively. Construct validity was tested through exploratory factor analysis and confirmatory factor analysis. Discriminant validity was assessed by Mann-Whitney U test to compare the scores on the Chi-MPCOSQ between 283 women with PCOS and 93 women without PCOS.ResultsExploratory factor analysis generated a 7-factor structure of the 30-item version of the Chi-MPCOSQ, which accounted for 77% of the overall variance. The Chi-MPCOSQ had high internal consistency (Cronbach’s α = 0.88) and good test-retest reliability (ICC = 0.89). Compared to PCOS patients, women without PCOS had consistently lower scores for every dimension of the Chi-MPCOSQ, demonstrating its good discriminant validity.ConclusionThe Chi-MPCOSQ is a valid and reliable instrument for measuring quality-of-life among Chinese women with PCOS.
Highlights
The modified polycystic ovary syndrome health-related quality-of-life questionnaire (MPCOSQ) is a 30item instrument measuring quality-of-life in English-speaking patients with polycystic ovary syndrome (PCOS)
Our results showed that the translated instrument had good validity and high test-retest reliability; it could discriminant well between Chinese women with and without Polycystic ovary syndrome (PCOS). 3
The diagnosis of PCOS was made by meeting at least two of the Rotterdam diagnostic criteria: (i) polycystic ovaries visualized by an ultrasound scan; (ii) clinical signs of hyperandrogenism and/or an elevated plasma testosterone level; and (iii) an interval between menstrual periods of 35 days and/or amenorrhea, which was defined as the absence of vaginal bleeding for at least 6 months
Summary
The modified polycystic ovary syndrome health-related quality-of-life questionnaire (MPCOSQ) is a 30item instrument measuring quality-of-life in English-speaking patients with polycystic ovary syndrome (PCOS). Polycystic ovary syndrome (PCOS) is a complex endocrine disorder in women of reproductive age. PCOS was usually associated with symptoms of emotional disturbance, weight gain, hirsutism (or body hair), acne, infertility, and menstrual irregularity [2]. These symptoms can be painful and uncomfortable and are often associated with reduced quality-of-life (QoL). Reduced QoL in PCOS is associated with life dissatisfaction, anxiety, and depression [3,4,5,6]. Assessment of QoL will provide important information for PCOS treatment, as well as intervention for and prevention of depression
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