Abstract

There is a need for a screening tool with capacities of accurate detection of early mild cognitive impairment (MCI) and dementia and is suitable for use in a range of languages and cultural contexts. This research aims to evaluate the psychometric and diagnostic properties of the Taiwan version of Qmci (Qmci-TW) screen and to explore the discriminating ability of the Qmci-TW in differentiating among normal controls (NCs), MCI and dementia. Thirty-one participants with dementia and 36 with MCI and 35 NCs were recruited from a neurology department of regional hospital in Taiwan. Their results on the Qmci-TW, Taiwanese version of the Montreal Cognitive Assessment (MoCA), and Traditional Chinese version of the Mini–Mental State Examination (MMSE) were compared. For analysis, we used Cronbach’s α, intraclass correlation coefficient, Spearman’s ρ, Kruskal–Wallis test, receiver operating characteristic curve analysis, and multivariate analysis, as appropriate. The Qmci-TW exhibited satisfactory test–retest reliability, internal consistency, and interrater reliability as well as a strong positive correlation with results from the MoCA and MMSE. The optimal cut-off score on the Qmci-TW for differentiating MCI from NC was ≤ 51.5/100 and dementia from MCI was ≤ 31/100. The MoCA exhibited the highest accuracy in differentiating MCI from NC, followed by the Qmci-TW and then MMSE; whereas, the Qmci-TW and MMSE exhibited the same accuracy in differentiating dementia from MCI, followed by the MoCA. The Qmci-TW may be a useful clinical screening tool for a spectrum of cognitive impairments.

Highlights

  • The number of people aged older than 65 years is increasing worldwide [1]

  • The total and most subtests of the Quick Mild Cognitive Impairment (Qmci)-TW, Montreal Cognitive Assessment (MoCA), and Mini– Mental State Examination (MMSE) scores of the Normal control (NC) were significantly higher than those of participants with mild cognitive impairment (MCI) and dementia groups, except for memory of the MoCA and registration, recall, naming, repetition, reading comprehension, verbal and executive function, and construction of the MMSE. Most of these scores were significantly higher in the MCI group than in the dementia group, except for repetition, abstraction, and orientation of the MoCA and registration, naming, repetition, and verbal and executive function of the MMSE

  • Some of the demographic and clinical characteristics, including age, educational level, Geriatric Depression Scale-Short Form score, and so on, were significantly different among the subjects of NC, MCI, and dementia (Tables 1 and 2), logistic regression analysis of MCI or dementia versus NC in all subjects (n = 102) revealed that after the keen competitions during the stepwise variable selection procedure, the MoCA score, food preparation score of the Lawton IADL scale in the past, and calculation score of the MMSE stayed in the final logistic regression model as the most important statistically significant predictors (Table 3)

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Summary

Introduction

The number of people aged older than 65 years is increasing worldwide [1]. The population of older people with dementia is expected to increase concurrently with global aging [2, 3]. The reported proportion of individuals with mild cognitive impairment (MCI) is expected even higher than of those with dementia [4, 5]; in clinical practice, most MCI cases in older adults remain unidentified. People with MCI are completely capable of self-. Psychometric and diagnostic properties of the Qmci-TW collection and analysis, decision to publish, or preparation of the manuscript

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