Abstract

This Mini-Review presents recent research into evidence for psychological treatments for people with severe and enduring anorexia nervosa (SEAN). Two psychological therapies, specialist supportive clinical management (SSCM), and cognitive behavior therapy for anorexia nervosa (CBT-AN) have limited (one randomized controlled study) evidence of efficacy. Both have had adaptations for SEAN, notably with revision of the primary treatment goal of improved quality of life and full weight recovery a secondary goal. A major issue with existing studies is poor definition of SEAN, and the large deficit in research that has used an agreed definition of SEAN. In particular, it may be problematic to extrapolate from studies of people with either severe and/or enduring but not intractable or “resistant” illness. People with longstanding AN who have not received evidence based care should be offered this with an expectation of recovery. Similarly, people with SEAN may be offered care with judicious mitigation of expectations. In the future, trials should include people with SEAN clearly defined. Trials with a subsample of participants likely to have SEAN, if identified at randomisation, are an opportunity for secondary analyses of such participants. This would widen the evidence base for psychological treatments providing hope for people with this devastating illness. Finally, there is an urgent need not only to strengthen our existing knowledge with studies of sufficient power, but also, fundamentally, to derive novel conceptualizations of what “treatment” involves.

Highlights

  • Anorexia nervosa (AN) is a serious mental disorder affecting 1.4% of women and 0.2% of men worldwide in their lifetime [1]

  • The 2012 review [13] did, identify several psychological therapies that appeared to address issues relevant to people with severe and enduring anorexia nervosa (SEAN), namely comorbidities of mood intolerance and depression, functional impairments, personality vulnerabilities and interpersonal deficits, low motivation to change, and/or modification of treatment goals towards quality of life. These therapies were: Specialist Supportive Clinical Management [specialist supportive clinical management (SSCM) [10]], cognitive behavior therapy for anorexia nervosa (CBT-AN) [11], the Community Outreach Partnership Program [COPP [14]], Maudsley Model of Anorexia Nervosa Treatment for Adults [MANTRA [15]], and that described by Strober [12]

  • At 12-month follow-up, people allocated to focal psychodynamic therapy (FPT) had significantly higher full recovery rates compared with those assigned to optimized treatment as usual (TAU) as usual, but there was no significant difference in recovery rates between the Cognitive Behavior Therapy (CBT)-E and FPT groups

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Summary

INTRODUCTION

Anorexia nervosa (AN) is a serious mental disorder affecting 1.4% of women and 0.2% of men worldwide in their lifetime [1]. The 2012 review [13] did, identify several psychological therapies that appeared to address issues relevant to people with SEAN, namely comorbidities of mood intolerance and depression, functional impairments, personality vulnerabilities and interpersonal deficits, low motivation to change, and/or modification of treatment goals towards quality of life These therapies were: Specialist Supportive Clinical Management [SSCM [10]], CBT-AN [11], the Community Outreach Partnership Program [COPP [14]], Maudsley Model of Anorexia Nervosa Treatment for Adults [MANTRA [15]], and that described by Strober [12]. Dalle-Grave CBT-E Trial In 2013, Dalle Grave et al [26] reported the immediate and longer-term effects of CBT-E in focused and broad forms in 80 young adults with severe AN and a median illness duration of 5 years In this RCT both treatments significantly improved weight, eating disorder and general psychopathology in participants, and whilst deterioration did occur after discharge, it was not marked and only for a short duration. Patients who underwent CRT in addition to TAU improved significantly more in eating disorder-

80 Median Adequate
32 Mean 10 Adequate
Findings
DISCUSSION
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