Abstract
Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder that increases the risk of inflammatory diseases by >3 fold, but the mechanisms remain elusive. Using a preclinical model of PTSD, we identified elevated calprotectin (+216%, p=0.0009), a pro-inflammatory protein, in the circulation of mice after psychological trauma. Calprotectin correlated with T-lymphocyte mitochondrial superoxide levels and inflammatory cytokine expression. Therefore, we hypothesized that psychological trauma leads to pro-inflammatory T-lymphocytes through calprotectin-mediated signaling, which predisposes inflammatory diseases.
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