Year-end Sale % OFF 
Abstract
BackgroundZinc is necessary for normal liver function; and vice versa, the liver plays a central role in zinc homeostasis. The aim of present study is to assess the effects of repeated psychological stress (PS) on the zinc metabolism and related mechanism involved in zinc homeostasis in rat liver.MethodsIn present study, we used communication box to create PS model and investigated the serum corticosterone (CORT), zinc level in serum and liver, liver metallothionein (MT) content and ZRT/IRT-like Protein 14 (ZIP14) mRNA expression.ResultsThe results showed that the serum CORT level increased and serum zinc level decreased significantly after 7 d and 14 d PS treatment. Meanwhile, zinc and MT contents in liver were elevated after 14 d PS exposure, while those in 7 d PS exposure group did not change. ZIP14 mRNA was expressed markedly at 7 d after the onset of PS, while Zip14 mRNA expression in the liver after 14 d PS exposure reached normal level compared with control group.ConclusionsThe results suggest that PS exposure could induce hypozincemia, which might be related to liver zinc accumulation because of high level of MT through glucocorticoid-mediated MT synthesis and ZIP14 expression induced by interleukin-6.
Highlights
Zinc is necessary for normal liver function; and vice versa, the liver plays a central role in zinc homeostasis
The interleukin-6 (IL-6) protein level in the serum was transiently elevated at 3 h after the onset of restraint stress, and the IL-6-responsive zinc transporter ZRT/IRT-like Protein 14 (ZIP14) mRNA in the liver was expressed markedly at 6 h [19]. These results suggest that ZIP14 plays a major role in the mechanism responsible for accumulation of zinc in the liver under restraint stress
ZIP14 mRNA expression in liver Time-dependent expression of Zip14 mRNA in the liver under psychological stress (PS) was examined by quantitative RT-PCR
Summary
Zinc is necessary for normal liver function; and vice versa, the liver plays a central role in zinc homeostasis. The aim of present study is to assess the effects of repeated psychological stress (PS) on the zinc metabolism and related mechanism involved in zinc homeostasis in rat liver. Zinc plays critical roles as a co-factor in numerous transcription factors and in a wide variety of biochemical processes and functions for over 300 different enzymes. It is an essential nutrient necessary for various biochemical and physiological functions, including growth, development, and sexual maturity in males and so on. The effect of PS on zinc metabolism is not fully characterized
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
