Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire.

Xia Chen,Lin Miao,Fei Wang,Ping Li,Guozhong Ji,Sihong You

doi:10.5005/jp-journals-10018-1230

Abstract

Aims and objectives:Gastroesophageal reflux disease (GERD) affects mental state and social activities. On the contrary, mental disorders may also play a crucial role in GERD symptoms. The purpose of the study was to analyze the data of Symptom Checklist 90-Revised (SCL-90-R) questionnaire from patients with persisting GERD and to explore the impact of psychological factors on them.Materials and methods:The patients accepted SCL-90-R questionnaire survey, following endoscopy, high-resolution manometry (HRM), and ambulatory impedance-pH monitoring. Based on these results, we divided patients into different groups. The result of SCL-90-R was also compared with degree of acid reflux, symptoms, symptom duration, and gender.Results:The data from 438 patients were analyzed. All patients were divided into reflux esophagitis (RE; 63, 14.38%); nonerosive gastroesophageal reflux disease (NERD; 106, 24.20%); functional heartburn (FH; 123, 28.08%), hypersensitive esophagus (HE; 67, 15.29%), diffuse esophageal spasm (DES; 5: 1.14%), hypertensive (10, 3.42%); weak peristalsis (14, 3.20%); achalasia (50, 11.42%). There were significant differences between different groups regarding depression (DEP), anxiety (ANX), paranoid ideation (PAR), and psychoticism (PSY). The patients with ≥2 years with GERD presented with increased scores in DEP, ANX, and PSY. Women had dramatically higher scores than men in each domain (p < 0.05).Conclusion:Data have shown that GERD patients exhibit differential levels of psychological symptoms. Long duration of GERD was related to typical plus atypical symptoms and females seem to be more prone to develop psychological disorders.How to cite this article: Chen X, Li P, Wang F, Ji G, Miao L, You S. Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire. Euroasian J Hepato-Gastroenterol 2017;7(2):117-121.

Highlights

Due to several factors, the incidence of Gastroesophageal reflux disease (GERD) has been increasing in Asian and Western countries.[1,2] Therapeutic strategy for GERD mainly involves the use of proton pump inhibitors (PPIs)
All patients were divided into reflux esophagitis (RE; 63, 14.38%); nonerosive gastroesophageal reflux disease (NERD; 106, 24.20%); functional heartburn (FH; 123, 28.08%), hypersensitive esophagus (HE; 67, 15.29%), diffuse esophageal spasm (DES; 5: 1.14%), hypertensive (10, 3.42%); weak peristalsis (14, 3.20%); achalasia (50, 11.42%)
All patients were divided into RE (63, 14.38%), NERD (106, 24.20%), FH (123, 28.08%), HE (67, 15.29%), DES (5, 1.14%), hypertensive (10, 3.42%), weak peristalsis (14, 3.20%), achalasia (50, 11.42%)

Summary

Introduction

The incidence of GERD has been increasing in Asian and Western countries.[1,2] Therapeutic strategy for GERD mainly involves the use of proton pump inhibitors (PPIs). Despite treatment with standard PPI dose, 20 to 30% of patients still suffer from troublesome GERD symptoms.[3] Persisting GERD symptoms cause discomfort, impair quality of life, and affect mental state and social activities. The subsequent development of mental disorders, such as ANX, and depressive symptoms plays a crucial role on GERD symptom deterioration and has a negative effect on people's quality of life.[4]. Some medical groups applied SCL-90-R to evaluate the psychological state of patients with chronic diseases.[5,6] Previous studies suggest that the SCL-90-R could be valuable in evaluating psychological factors and, recommend it for psychosocial investigation in varied disease clinical practice.[7,8,9] data from patients

Methods

Results

Discussion

Conclusion