Abstract
Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI). Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale. Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05). Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.
Highlights
Pathology processes of major neurocognitive disorder begin before the onset of clinical symptoms
Using a resting-state functional magnetic resonance imaging approach, we investigated linear trends of the orbitofrontal gyrus (OFG)/AMG/hippocampus (HP)/parahippocampal gyrus (PHG) functional connectivity (FC) according to the level of resilience scale
For FCs exhibiting significant linear trends, we further investigated whether such trends of connection strengths are related to Montgomery– Asbergo Depression Rating Scale (MADRS), Mini Mental State Examination (MMSE), and Beck Anxiety Inventory (BAI) scores or not
Summary
Pathology processes of major neurocognitive disorder begin before the onset of clinical symptoms. Of the many aspects of brain resilience, interest in psychological resilience and its mechanism has increased in terms of major neurocognitive disorder prevention. To address this issue, it is required to assess functional network in brain. Network resilience derives from the efficient arrangement of connections between brain regions [2, 3]. It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI)
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