Psychological continuum of elderly hypertensive patients with metabolic syndrome receiving chronotherapy with a fixed-dose combination of amlodipine, lisinopril and rosuvastatin

N M Agarkov,O I Okhotnikov,E A Markelova,A M Markelova,V I Kolomiec,E O Moskaleva,S I Korneeva,A A Moskalev

doi:10.15829/1560-4071-2021-4312

Abstract

Aim. To study the psychological continuum of elderly hypertensive patients with metabolic syndrome (MS) receiving chronotherapy with a fixed-dose combination of amlodipine, lisinopril and rosuvastatin.Material and methods. In a clinical setting, 63 hypertensive patients with MS aged 60-74 years (experimental group) received chronotherapy with fixed-dose combination of amlodipine, lisinopril and rosuvastatin (Ekvamer®) at a dose of 5/10/10 mg in the evening (8 pm). The control group of hypertensive patients with MS aged 60-74 years old (n=58) received Ekvamer® in the morning (conventional therapy) at the same dosage.Results. With fixed-dose combination of amlodipine, lisinopril and rosuvastatin, the severity of psychological continuum abnormalities significantly decreases after 1 year in the chronotherapy regimen (evening intake) than with morning intake with an equivalent dosage of 5/10/10 mg per day in both cases. The dynamics of cognitive impairments in hypertensive patients aged 60-74 years with MS using chronotherapy regimen is characterized by a significant increase in the mean MMSE score from the initial 17,8±0,3 to 23,5±0,4 points (p±0,001) vs 16,9±0,3 to 20,4±0,4 points (p<0,001) when taking the drug in the morning. Situational anxiety decreased from 40,0±2,2 to 30,6±1,8 points (p<0,05) vs 40,8±2,5 to 33,5±1,9 points (p<0,05), personal anxiety from 48,8±2,0 to 26,4±1,9 (p<0,001) vs from 44,9±1,9 to 30,7±1,7 (p<0,01) points, respectively. Depressive disorders slightly decreased with chronotherapy (14,1%) vs 7,7% than with the conventional scheme, but despite this, they corresponded to depressive spectrum disorders in both groups.Conclusion. The results obtained indicate a greater efficiency of chronotherapy than the conventional use of fixed-dose combination of amlodipine, lisinopril and rosuvastatin in hypertensive patients with MS.

Highlights

артериальной гипертензией (АГ) — артериальная гипертензия, КГ — контрольная группа, метаболическом синдроме (МС) — метаболический синдром, ОГ — основная группа, фиксированной комбинацией (ФК) — фиксированная комбинация, MMSE — Mini-Mental-State-Examination, CES-D — Center for Epidemiologic Studies — Depression
With fixed-dose combination of amlodipine, lisinopril and rosuvastatin, the severity of psychological continuum abnormalities significantly decreases after 1 year in the chronotherapy regimen than with morning intake with an equivalent dosage of 5/10/10 mg per day in both cases
The dynamics of cognitive impairments in hypertensive patients aged 60-74 years with metabolic syndrome (MS) using chronotherapy regimen is characterized by a significant increase in the mean MMSE score from the initial 17,8±0,3 to 23,5±0,4 points (p±0,001) vs 16,9±0,3 to 20,4±0,4 points (p

Summary

Introduction

АГ — артериальная гипертензия, КГ — контрольная группа, МС — метаболический синдром, ОГ — основная группа, ФК — фиксированная комбинация, MMSE — Mini-Mental-State-Examination, CES-D — Center for Epidemiologic Studies — Depression. И. — д.м.н., профессор кафедры лучевой диагностики и терапии, ORCID: 0000-0002-6685-3183, Корнеева С. А. Психологический континуум пожилых пациентов, страдающих артериальной гипертензией при метаболическом синдроме, на фоне хронотерапии фиксированной комбинацией амлодипина, лизиноприла и розувастатина. Aim. To study the psychological continuum of elderly hypertensive patients with metabolic syndrome (MS) receiving chronotherapy with a fixed-dose combination of amlodipine, lisinopril and rosuvastatin.

Results

Conclusion