Psychogenic Movement Disorder After H1N1 Influenza Vaccination

Abstract

Back to table of contents Previous article Next article LettersFull AccessPsychogenic Movement Disorder After H1N1 Influenza VaccinationChien-Yu Lin, M.D., Chun-Chih Peng, M.D., Hui-Ching Liu, M.D., and Nan-Chang Chiu, M.D.Chien-Yu LinSearch for more papers by this author, M.D., Chun-Chih PengSearch for more papers by this author, M.D., Hui-Ching LiuSearch for more papers by this author, M.D., and Nan-Chang ChiuSearch for more papers by this author, M.D.Published Online:1 Jul 2011AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: The term “psychogenic movement disorder” refers to movement disorder of psychogenic origin. The emerging importance of psychogenic movement disorder in children is worth our attention.1 The 2009 pandemic influenza A(H1N1) virus (H1N1v) caused large-scale infection and anxiety in public worldwide since May 2009. The Centers for Disease Control, Taiwan, adopted several aggressive strategies, including universal vaccination against H1N1 virus. The concern about the safety and efficiency of universal vaccination was widely spread in the public, and psychogenic reaction to the vaccines was found.We report on a girl, age 7 years, 9 months, with psychogenic movement disorder after H1N1 vaccination. We focus on the psychogenic impact of universal influenza vaccination.Case ReportThis straight-A second-grade elementary school student was admitted for abrupt-onset seizure-like movements. She presented with uncontrolled bilateral hand movements 1 day after the first dose of H1N1 vaccination at school (non-adjuvanted H1N1v vaccine, AdimFlu-S (A/H1N1) Adimmune Corp., Taichung, Taiwan; 0.5 ml, IM injection). The intermittent hand movements persisted and progressed to lower limbs in the next 2 weeks. Both horizontal and vertical movements of bilateral legs were noted, which were dysrhythmic and incongruent with a classical organic movement disorder. Her consciousness remained clear, and she could communicate with her family throughout the course. The duration of each episode was variable, and it sometimes persisted for more than 1 hour. She was hospitalized for evaluation of suspected status epilepticus, and her abnormal movements were partially relieved by diazepam or dormicrium. Complete blood counts, biochemistry, CSF study, infectious-pathogen studies, and awake electroencephalography were unremarkable. Psychogenic illness was highly suspected when her movements subsided after suggestion and placebo injection with normal saline. Further stressors were identified, including high scholarship expectation of her parents and bullying at school. The diagnosis of psychogenic movement disorder was established, and psychotherapy was given. Occasional abnormal limb movements were noted after discharge but did not disturb her daily life.Pandemic infectious disease can lead to psychogenic illness, for example, somatic symptoms and anxiety. The first patient with H1N1v infection in Taiwan was identified on May 20, 2009, and anxiety spread in the general public soon. A universal-vaccination program was carried out to control the pandemic. The systemic reaction after H1N1v vaccination is around 53.8%, and symptoms are mild and self-limiting.2 However, doubt and distrust regarding the safety and efficacy of vaccination developed in the public, and the possible adverse effects were amplified and overemphasized, regardless the substantive relationship with vaccination. Public psychogenic illness after vaccination is reported as “mass psychogenic illness” or “psychogenic hysteria.”3 The etiology is not clear, but it is not regarded as the result of vaccination itself. The mass media plays an important role in disseminating and sensationalizing vaccine objections, although some information is incorrect or unconfirmed.4 Children are more susceptible to group anxiety, and the atmosphere in the place vaccinated enhances the fear and anxiety. Many school children cry before intramuscular injection, and they feel dizzy and weak along with their classmates.Psychogenic movement disorder remains a diagnostic challenge to physicians, and most are diagnosed after age 10.5 The diagnosis of psychogenic movement disorder is difficult, and the prevalence is about 3.1% in pediatric movement-disorder populations.1 Anticipating stressors, secondary gain, and malingering are frequently noted in patients with psychogenic movement disorder, and precipitants are common, such as trauma or major emotionally stressful life events. Our patient is relatively younger, and psychogenic movement disorder after vaccination has rarely been reported previously.In conclusion, the emerging importance of psychiatric disorder in children raises our attention. In facing the pandemic infection, psychogenic stress should be concerned and the idea that a universal vaccination program may result in mass psychogenic illness. Psychogenic movement disorder is easily neglected in children, and it may be precipitated by influenza vaccination.Department of Pediatrics, Hsinchu Mackay Memorial Hospital, Hsinchu City, Taiwan,Mackay Medicine, Nursing and Management College, Taipei, Taiwan TaipeiMedical University School of Respiratory Therapy, TaiwanDepartment of Psychiatry, Mackay Memorial Hospital, Taipei, TaiwanCorrespondence: Dr. Nan-Chang Chiu, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan e-mail: [email protected]mmh.org.twC.Y. Lin involved in writing the first draft, patient assessment, and follow-up. C.C. Peng was involved in patient assessment and intensive care. H.C. Liu was involved in psychiatric evaluation and psychotherapy. N.C. Chiu was involved in review and critique, patient assessment, and follow-up.1. Ferrara J , Jankovic J : Psychogenic movement disorders in children. Mov Disord 2008; 23:1875–1881Crossref, Medline, Google Scholar2. Greenberg ME , Lai MH , Hartel GF , et al.: Response to a monovalent 2009 influenza A (H1N1) vaccine. N Engl J Med 2009; 361:2405–2413Crossref, Medline, Google Scholar3. Clements CJ : Mass psychogenic illness after vaccination. Drug Saf 2003; 26:599–604Crossref, Medline, Google Scholar4. Kata A : A postmodern Pandora's box: anti-vaccination misinformation on the internet. Vaccine 2010; 28:1709–1716Crossref, Medline, Google Scholar5. Valadi N , Morgan JC , Sethi KD : Psychogenic movement disorder masquerading as CJD. J Neuropsychiatry Clin Neurosci 2006; 18:562–563Link, Google Scholar FiguresReferencesCited byDetailsCited ByVaccine-Induced Functional Neurological Disorders in the Covid-19 Era25 April 2022 | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 365Movement disorders, cerebral palsy and vaccinationEuropean Journal of Paediatric Neurology, Vol. 36Immunization stress-related responses: Implications for vaccination hesitancy and vaccination processes during the COVID-19 pandemicJournal of Anxiety Disorders, Vol. 84Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder6 August 2021 | Journal of Neurology, Neurosurgery & Psychiatry, Vol. 92, No. 11Functional Neurological Disorder After SARS-CoV-2 Vaccines: Two Case Reports and Discussion of Potential Public Health ImplicationsMatthew Butler, M.D., Jan Coebergh, M.D., Farinaz Safavi, Ph.D., Alan Carson, Ph.D., Mark Hallett, M.D., Benedict Michael, Ph.D., Thomas A. Pollak, Ph.D., Tom Solomon, Ph.D., Jon Stone, Ph.D., Timothy R. Nicholson, Ph.D.; 15 July 2021 | The Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 33, No. 4Defining Causality in Neurological & Neuropsychiatric COVID-19 Vaccine Complications: What Have We Learnt from Current and Previous Vaccination Campaigns?SSRN Electronic JournalFunctional Neurological Disorder After SARS-CoV-2 Vaccines: Two Case Reports and Discussion of Potential Public Health ImplicationsSSRN Electronic Journal, Vol. 383Functional Movement Disorders in Children12 November 2020 | Frontiers in Neurology, Vol. 11Psychogenic movement disorders in children and adolescents: an update11 January 2019 | European Journal of Pediatrics, Vol. 178, No. 4 Volume 23Issue 3 Summer 2011Pages E37-E38 Metrics C.Y. Lin involved in writing the first draft, patient assessment, and follow-up. C.C. Peng was involved in patient assessment and intensive care. H.C. Liu was involved in psychiatric evaluation and psychotherapy. N.C. Chiu was involved in review and critique, patient assessment, and follow-up.PDF download History Published online 1 July 2011 Published in print 1 July 2011