Abstract
Psycho-emotional stress is one of the risk factors for metabolic syndrome and related diseases. Hence, this study has designed to the effect of psycho-emotional stress in the form of immobilization stress in rabbits. In this study, we used 12 m ale New Zealand White rabbits (2.5 -3 kg body weight), Six animals for hanging fixation and another six as control. Blood samples were taken before hanging (0 minute) and at 60, 120 minutes. Serum was separated and used for the estimation of various biochemical parameters. Hanging fixation appears to produce significant increase in malondialdehyde and lipid profile levels. The non-enzymatic antioxidants like reduced glutathione, vitamin E and ceruloplasmin were found to be decrease and the level of enzymatic antioxidant like glutathione peroxidase was increased significantly. The results reveal that the hanging fixation may develop coronary artery disease. This is the area, which should be evaluated further by carrying out chronic studies in hun g stress and by histopathological studies.
Highlights
Psycho-emotional stress is acting upon a large human population in the entire country due to various metabolic symptoms
Likewise lipid hydroperoxide level was found to be increased at 60 and 120 minutes significantly (p
The level of non-enzymatic antioxidants like Vitamin E, reduced Glutathione and ceruloplasmin were found to be decreased significantly (p
Summary
Psycho-emotional stress is acting upon a large human population in the entire country due to various metabolic symptoms. It induces strain upon both emotional and physical endurance, which has been considered to be a basic factor in the aetiology of a number of diseases e.g. cardiovascular diseases, cancer, diabetes mellitus, etc. Psycho-emotional stress is one of the most potent stress models in rabbit It strongly activates both components of the sympathoadrenal system [16] The release of catecholamines has immediate effects on both metabolism and the cardiovascular system. It produces cell injury in several tissues. Alterations in mitochondria ultra-structure has been observed in the heart of immobilized animals [14]
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