Psychoactive Substances and Drugs-Medicament and Narcotic

Abstract

Toxicological analysis is a complex set of tasks aiming to estimate how much time has elapsed since a drug was last consumed or to inform about its chronic consumption. It is also worth paying attention to the fact of using psychoactive substances induce euphoria or increase physical energy. The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics could be used to adapt pain medication based on an individual’s genetic background. Many potential genetic markers related to xenobiotics metabolism have been described. Such predictors are especially of value for neonates and young children, in which case the assessment of efficacy is complicated by imprecise/poor communication. The knowledge of opioids metabolism is essential also for older patients and those with comorbidities, who receive multiple medications and may have impaired renal and hepatic function.