Abstract

The purpose of these experiments was to gain comparative information about psychoactive compounds on experimental convulsions, a phenomenon that has been used as an index of CNS excitability. LSD, mescaline, d- and 1-amphetamine, cocaine and morphine were all effective in blocking audiogenic seizure susceptibility. None of the compounds were effective in blocking the priming of a non-susceptible strain of mice. This latter finding differentiates these compounds from Δ 9-tetrahydrocannabinol which has been previously reported to block priming.

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