Abstract
This article will outline the newly developing stereological methods of quantitation. Such techniques are becoming increasingly relevant to investigations of psychiatric disorders. Sensitive and accurate methods of detecting cellular alterations are essential when studying disorders such as schizophrenia and mood disorders in which the microscopic brain changes are subtle. This review will firstly address issues of sampling the brain tissue for quantitative studies, secondly the various probes that are available for assessing cell number and size will be mentioned, and finally the principles of assessing cell spatial arrangement will be discussed. Examples of stereological studies of psychiatric disorders are included.
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