Psychiatrische Erkrankungen mit Stammzelltechnologien verstehen

Abstract

It is a challenge to establish and use model systems for the study of complex neuropsychiatric diseases such as schizophrenia (SZ) and autism spectrum disorder (ASD). The development of induced pluripotent stem cell (iPSC) technologies now offers a promising approach which faithfully represents the varying genetic background of individual patients. Phenotypic analysis of iPSC-derived neurons reveals differences at the level of transcriptomes and calcium signalling allowing for a specific discrimination between SZ and ASD phenotypes.