Psychiatric symptoms, emotional distress and suicide in Wilson disease

Abstract

individuals were involved in the stud),'. Penpheral sensory nen:e function was assessed on lower and upper extremities, stanclard cardiovascular reflex tests and 24-hour HRV measumments were performed. Results: Ahhoogh the data tbr WD patients, in general, were in the norn~al range, current perception threshold (CPT) was s~gnificantly reduced fbr the peroneal nerve in WD (p = 0~002). The heart rate variations after standing up and the blood pressure response to sustained handgnp (p<0.05), as well as the time and frequency domain parameters of HRV were significantly lvduced in patients with neurological symptoms compared to those without. However, one patient had prominent damage of the median nerve, and 2 panents presented with abnormal cardiovascular reflex tests. One frequency domain parameter con'elated with the diastolic ABPM parameters in Wilson patients. Condusion: This is the first report in WD patients on peripheral sensory neuropathy and autonomic neuropathy based on a sensitive 24-hour heart rate variability analysis. Sensor),' neuropathy may be the result of direct to~c ettect of copper or consequence of liver damage. Altered autonotnic function may be caused by copper deposition m the autonomic regulator) cemers in the brain.