Psychiatric genetics, neurogenetics, and neurodegeneration.

Berit Kerner

doi:10.3389/fgene.2014.00467

Abstract

Psychiatric genetics, neurogenetics, and neurodegeneration.

Highlights

Neuropsychiatric disorders are common, complex, and severe disorders that affect the core of a person: their emotions, intellect, and ability to self-regulate
Using personality traits in centennials as an example, Bae et al demonstrate and discuss the analytical and translational challenges of Genome Wide Association Studies (GWAS) in common complex disorders brought about by populationspecific allele frequencies, which often hinder the replication of statistically significant results (Bae et al, 2013)
Krebs et al uses the example of movement disorders to demonstrate the genetic pleiotropy and heterogeneity governing the relationship between genotype and phenotype (Krebs and Paisán-Ruiz, 2012)

Summary

Introduction

Neuropsychiatric disorders are common, complex, and severe disorders that affect the core of a person: their emotions, intellect, and ability to self-regulate. Using personality traits in centennials as an example, Bae et al demonstrate and discuss the analytical and translational challenges of Genome Wide Association Studies (GWAS) in common complex disorders brought about by populationspecific allele frequencies, which often hinder the replication of statistically significant results (Bae et al, 2013).

Results

Conclusion