Abstract

While studying alkaloid natural products and their derivatives, Sandoz chemist Albert Hofmann had to leave the lab early one day in 1943 because he’d accidentally been exposed to one of his products, lysergic acid diethylamide (LSD). As he wrote in his memoir, “ LSD—My Problem Child,” he later reported to his department director: “I was forced to interrupt my work in the laboratory in the middle of the afternoon and proceed home, being affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed … I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.” In the decades that followed, various researchers pursued LSD and other psychoactive compounds for medical uses,

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