Abstract
Carcinoma of unknown primary (CUP) has historically been reported to account for 3-5% of all cancers, more recently for 1-2%, and is itself a rare cancer. The most common subtype of CUP is adenocarcinoma, followed by poorly differentiated carcinoma, squamous cell carcinoma, neuroendocrine tumor. The increasing use of immunohistochemistry (IHC) and chromosome/genetic testing has enabled us to identify rarer diseases of CUP. When an apocrine carcinoma of unknown primary is encountered, the differential diagnosis between carcinoma metastasizing to the skin and primary cutaneous apocrine carcinoma is challenging, but can be distinguished by a clinical-pathological correlation.
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