P-Sulfonatocalix[6]arene is an effective coacervator of poly(allylamine hydrochloride).

Abstract

p-Sulfonatocalix[6]arene is shown to form insoluble complexes with poly(allylamine hydrochloride) when the charge balance between the negative calixarene sulfonate groups matches the positive charge carried by the polyelectrolyte, this makes this glycosylaminoglycan analog an interesting candidate for controlled release systems in the case of proteins encapsulated in mesoscopic complexes with polyelectrolytes.