Abstract
A highly efficient polymer supported palladium-N–heterocyclic carbene (PS-Pd–NHC) catalytic system has been developed for direct reductive amination (DRA) of carbonyl compounds with primary/secondary amines in aqueous reaction medium. This new catalytic system represents a heterogeneous, recyclable and environmentally benign protocol. The developed methodology describes a simple one step approach for the synthesis of a wide variety of substituted amines exhibiting remarkable activity with excellent yield of a desired product. Furthermore, the catalyst was effectively recycled for six consecutive cycles without any significant loss in its catalytic activity.
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