PS-P06-13: THE IMPACT OF BODY COMPOSITION AND ADIPOSE DISTRIBUTION ON BLOOD PRESSURE IN YOUNG AND MIDDLE-AGED ADULTS

Abstract

Background and Aims: Both body size and composition are related to BP elevation. Body adipose mass and lean/muscle mass are closely related, and thus the mutual adjustment is important when investigating the impact of one of them on BP. Besides, the proportionate contributions of various components of body composition on BP remains unknown. Thus, in the present study, by constructing models including body fat mass in various depots and body muscle mass simultaneously, we aimed to comprehensively investigate the impact of body composition and adiposity distribution on BP in young and middle-aged adults. Methods: 14412 participants with available data on whole-body DXA measurement derived from the National Health and Nutrition Examination Survey were included. Multiple stepwise linear regression models of BP on various components of body composition were built to evaluate the true determinants of BP in terms of body composition. Then, relative importance analysis was performed to quantify the contributions of various components of body composition and adipose distribution. Results: The mean age of the participants was 36 years and there were 50.7% women. Linear regression with mutual adjustment showed that total fat mass, total muscle mass, and trunk fat mass were significantly and positively associated with BP, respectively; however, arm and leg fat mass were significantly and negatively associated with BP. After adjusted for potential covariates, SBP were significantly determined by trunk fat mass (β; = 0.33, P < 0.001), leg fat mass (β; = -0.12, P < 0.001), and total muscle mass (β; = 0.10, P < 0.001); DBP were significantly determined by trunk fat mass (β; = 0.52, P < 0.001), leg fat mass (β; = -0.15, P < 0.001), arm fat mass (β; = -0.23, P < 0.001), and total muscle mass (β; = 0.06, P < 0.001) in men. Similar results were observed in women. Relative importance analysis indicated that trunk fat mass was the major contribution to SBP and DBP in both men and women; meanwhile, total muscle mass also made relatively great contribution to SBP for men and women. Conclusions: Both fat mass and muscle mass were independently associated with and substantially contributed to SBP in both men and women. After adjustment for other measurements of body composition and potential covariates, trunk fat mass was positively associated with BP and was the most dominant contributor to BP; however, leg fat mass was negatively associated with BP.