Abstract
Objective: High systolic blood pressure (HSBP) remains the leading risk factor for atrial fibrillation/atrial flutter (AF/AFL) worldwide. However, limited quantitative research has revealed the specific AF/AFL burdens due to HSBP. This study aimed to estimate the global burden of AF/AFL attributable to HSBP by region, sex, and age. Design and method: Data on HSBP-related AF/AFL burden was extracted from the 2019 Global Burden of Disease (GBD) study. Numbers and age-standardized rates of deaths, disability-adjusted life years (DALYs) and corresponding estimated annual percentage change (EAPC) were discussed by age, sex, socio-demographic index (SDI) and locations. Results: Globally, HSBP-related AF/AFL caused 107,091 deaths and 3,337,876 DALYs in 2019, an increase of 142.5% and 105.9% from 1990, respectively. The corresponding mortality and DALYs rates dropped by 5.8% and 7.7%, respectively. Almost half of the HSBP-related AF/AFL burden was bore by high and high-middle SDI regions and it was experiencing a shift from high and high-middle SDI regions to lower SDI regions. In general, females and elderly people tended to have a higher HSBP attributable AF/AFL burden. In addition, young adults (30–49 years old) experienced an annual increase in global deaths and DALYs rates. V-shaped correlation was detected between SDI and HSBP-related AF/AFL burden. Conclusions: HSBP attributable AF/AFL burden has been an incremental public health concern worldwide, with heterogeneities across regions, sexes and ages. Geographically and sexually tailored strategies were required to reduce the burden of hypertension-related AF/AFL.
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