Abstract
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015. During a mean follow-up of 5.18 years, 43,792 patients were newly diagnosed with psoriasis. In Cox proportional hazard models, patients with NPDR (hazard ratio [HR] 1.26) had a higher incidence of psoriasis and patients with PDR patients had a higher risk of psoriasis (HR 1.35). ESRD was defined by the ICD-10 code, including chronic kidney disease/renal failure, transplantation, and dialysis. The incidence of psoriasis increased in DR patients with ESRD (HR 2.99, 95% CI 2.49–3.59, p < 0.001) compared to non-DR patients without ESRD. This is the first association study between psoriasis and diabetic complications including DR and ESRD. DR and its severity were related to the onset of psoriasis. In addition, ESRD was related with an increased psoriasis in DR patients.
Highlights
Psoriasis is a skin disorder with chronicity that is known to have a prevalence of about 2–4%1
This research presented as follows: (1) the presence of non-proliferative DR (NPDR) and proliferative DR (PDR) was an risk factor of psoriasis onset in Diabetes mellitus (DM) patients, and (2) end-stage renal disease (ESRD) was one of the predictors of psoriasis risk in diabetic patients and the presence of ESRD further increased the incidence of psoriasis in Diabetic retinopathy (DR) patients
Another study reported increased DM risk in psoriatic patients, and the risk increases with the duration and severity of psoriasis[18]
Summary
Psoriasis is a skin disorder with chronicity that is known to have a prevalence of about 2–4%1. Psoriasis is considered to be a systemic disease associated with various comorbidities such as cardiovascular disease, stroke, hypertension, dyslipidemia, diabetes, metabolic syndrome, and obesity[5,6]. Diabetes in patients with psoriasis implies a risk for stroke. Diabetes is associated with the development of other diseases, and the health burden for diabetes is expected to continually increase. In a recent meta-analysis, patients with psoriasis were shown to have an increased risk of diabetes, and the pooled OR was 1.76 (95% CI 1.59–1.96) in the random effect model analysis[9]. Overt diabetic nephropathy can lead to end-stage renal disease (ESRD). There is little known about the potential effects of DR or ESRD on psoriasis. The present study examined the link between DR/ESRD and the psoriasis risk in diabetic patients through a population-based cohort study
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
