Psoriasis related acute leukemia: a clinical study of 39 cases

Abstract

Objective To explore the clinical features, curative effects and prognosis of patients with psoriasis related acute leukemia. Methods The clinical data of 39 cases in the Second Hospital Shanxi Medical University from January 2011 to June 2016 were collected, and their clinical features and prognosis were analyzed retrospectively. Results Of 39 patients, 28 were males and 11 were females, with the median age of 42 years (13-76 years), the median time that suffering from psoriasis were 10 years (1-30 years); There were 23 (59.0%) patients with acute promyelocytic leukemia (APL), 13 (33.3%) patients with acute myeloid leukemia (AML) and 3 (7.7%) patients with B-cell acute lymphocytic leukemia (B-ALL). In patients with recurrence, there were 4 patients with APL, 4 patients with AML, and 1 patient with B-ALL. Single factor analysis showed that the type of PML-RARα fusion gene isoform and the time of suffering from psoriasis were the influencing factors of patients with APL recurrence (both P 0.05) based on multivariate analysis. The complete remission (CR) rates of patients with psoriasis related APL and AML were 96% (22/23) and 46% (6/13), the 3-year overall survival (OS) rates were 96% and 44%, 3-year relapse free survival (RFS) rates were 77% and 38%, respectively. Conclusions In patients with psoriasis related acute leukemia, the largest population is APL patients, and they have a better prognosis. However, patients with psoriasis related AML and ALL have low CR rate and OS rate, and the allogeneic hematopoietic stem cell transplantation should be considered after remission. Key words: Leukemia, acute; Psoriasis; Treatment outcome; Prognosis