Abstract
Background: There is a scarcity of literature on co-existing psoriasis (Ps) and systemic lupus erythematosus (SLE). We used a large national population database to determine if there is any association between Ps and SLE. The primary objective was to compare the odds of being admitted for SLE in patients with Ps compared to those without Ps. The secondary objective was to compare hospital outcomes of patients admitted for SLE with co-existing Ps to those without Ps.Methods: Data were abstracted from the National Inpatient Sample (NIS) 2016 and 2017 Databases. We search for hospitalizations using ICD-10 codes. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders.Results: There were over 71 million discharges included in the database. A total of 20,630 hospitalizations had SLE as the principal diagnosis. One hundred fifty (0.7%) of these SLE hospitalizations have co-existing Ps. Hospitalizations for SLE with co-existing Ps had similar length of stay (LOS), total hospital charges, need for blood transfusion, odds of having a secondary discharge diagnosis of venous thrombosis or embolism/pulmonary embolus, and acute kidney injury compared to those without Ps. Hospitalizations with a secondary diagnosis of Ps have an adjusted odds ratio (AOR)=2.73 (95% CI 1.86-4.02, P<0.0001) of SLE being the principal reason for hospitalization compared to hospitalizations without Ps.Conclusion: In our study, patients with Ps had almost three times the odds of being admitted for SLE compared to non-Ps patients. However, Ps patients admitted for SLE had similar hospital outcomes compared to non-Ps patients admitted for SLE.
Highlights
Psoriasis (Ps) and systemic lupus erythematosus (SLE) are two rheumatologic conditions that typically present with cutaneous manifestations but are both characterized by systemic inflammation and a pronounced autoimmune background [1,2]
Hospitalizations with a secondary diagnosis of Ps have an adjusted odds ratio (AOR)=2.73 of SLE being the principal reason for hospitalization compared to hospitalizations without Ps
Only 0.7% of hospitalizations for SLE had co-existing Ps in our study, patients with Ps had almost three times the odds of being admitted for SLE compared to non-Ps patients
Summary
Psoriasis (Ps) and systemic lupus erythematosus (SLE) are two rheumatologic conditions that typically present with cutaneous manifestations but are both characterized by systemic inflammation and a pronounced autoimmune background [1,2]. Both diseases are driven by immune dysfunction and are associated with extra-cutaneous manifestations, with arthritis being common to both. Often a feature of both diseases, is one of the largest global contributors to patient disability Both diseases impart an overall increased risk of mortality compared to the general population [8,9].
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