Abstract
Psoriasis, chronic eczema and atopic dermatitis are the most common diseases among patients of dermatovenereological profile. The study of the etiology and pathogenesis of chronic dermatoses, and the grounded choice of their treatment are extremely important problems of modern medicine. The objective of this work was to study the peculiarities of functioning of sympathoadrenal and vagal-insular systems in male patients with psoriasis, chronic eczema and atopic dermatitis. Materials and methods. 115 healthy males and males who suffered from psoriasis, chronic eczema and atopic dermatitis were examined. The men were distributed in the study groups depending on their age and the presence of chronic dermatoses. We investigated levels of adrenaline, norepinephrine, dioxyphenylalanine, dopamine in urine, as well as the levels of insulin and cortisol in blood. The calculation of hormones and mediators ratios of the sympathoadrenal and autonomic systems was performed. Results. Sympathoadrenal system was less active and its reserve capacity was lower in males with psoriasis, chronic eczema and atopic dermatitis. We also fixed the acceleration of biosynthesis of catecholamines. The speed of transformation of dioxyphenilalanine and dopamine to their metabolites was higher in patients with psoriasis, chronic eczema and atopic dermatitis. The high tension of glucocorticoid function of adrenal glands and increased activity of autonomic system; the intensive violations of autonomic homeostasis; the reduction of activity of compensatory organism reactions were found in male patients with chronic dermatoses. The discoordinated relationships in neurogenic link of adaptation in patients with chronic dermatoses were fixed. An antagonistic relationship was also revealed between different branches of nervous system in patients with psoriasis, chronic eczema and atopic dermatitis. These data reflected the violations of adaptation in patients with chronic dermatoses. Conclusions. The obtained results indicate the existence of irregularities in the functioning of the sympathoadrenal and autonomic systems. The results of investigation substantiate the feasibility of corrective measures in male patients with chronic dermatoses (such as psoriasis, chronic eczema, atopic dermatitis), by the using of drugs that improve metabolism in the brain.
Highlights
Psoriasis, chronic eczema and atopic dermatitis are the most common diseases among patients of dermatovenereological profile
Materials and methods. 115 healthy males and males who suffered from psoriasis, chronic eczema and atopic dermatitis were examined
Sympathoadrenal system was less active and its reserve capacity was lower in males with psoriasis, chronic eczema and atopic dermatitis
Summary
We examined 115 males, who either suffered from psoriasis, chronic eczema and atopic dermatitis, or did not have any manifestations of dermatological pathology and formed control group. The activity of sympathoadrenal system was checked by levels of catecholamines and dioxyphenylalanine. Their concentration reflects the activity of suprarenal glands and hypothalamus. To compare the data in different groups we used paired Student’s t-test with the calculation of arithmetic mean value (M) and the standard error of the arithmetic average (m). The normality of data distribution was checked using the Shapiro-Wilk test at the significance level of 0.01. When we evaluated the received data, the level of significance was taken as 0.05 (the differences between the data were considered reliable at p
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