Abstract
BackgroundPsoriasis is a chronic inflammatory skin condition commonly associated with psoriatic arthritis, malignancy, diabetes, inflammatory bowel disease, and cardiovascular disease. Several reports and studies have reported an association between psoriasis and non-ischemic dilated cardiomyopathy (NIDCM). We aim to study the relationship between psoriasis and non-ischemic dilated cardiomyopathy in a large population-based study.MethodsWe utilized the Healthcare Cost and Utilization Project National Inpatient Sample 2017 database, which represents a 20% sample of all payer hospitalizations in the United States. We investigated hospitalizations for patients aged 18 years old or older with diagnoses of any type of psoriasis and non-ischemic dilated cardiomyopathy. Psoriasis, cardiomyopathy, and other comorbidities were identified through their international classification of diseases, 10th revision codes recorded in the discharge record for each hospitalization.ResultsOf a total of 6,084,184 all-cause admissions, 0.5% were admissions for patients with psoriasis (n = 32,807). Of the patients with and without psoriasis who had non-ischemic dilated cardiomyopathy, after adjusting for age, sex, race, diabetes mellitus, hypertension, alcohol abuse, cocaine abuse, arrhythmias, and obesity in a multivariate analysis, the presence of psoriasis was not significantly associated with non-ischemic dilated cardiomyopathy.ConclusionPsoriasis is a chronic autoimmune disorder which carries a higher cardiovascular events and more prevalent traditional atherosclerotic risk factors in comparison to the general population. However, association with non-ischemic cardiomyopathy or NIDCM in particular has not been studied sufficiently. Our study, being one of the first larger studies to assess this correlation, indicated no relationship between psoriasis and non-ischemic dilated cardiomyopathy.
Highlights
Psoriasis is a chronic inflammatory skin condition which commonly presents with scaly erythematous plaques
Outcomes We aimed to investigate if psoriasis represents an independent risk factor for non-ischemic dilated cardiomyopathy (NIDCM)
Despite several previous studies and data that demonstrated the association of adverse cardiovascular risk factors and events with psoriasis or psoriatic arthritis [5,6,7,8,9,10,11,12,13], our present study found that no increased occurrence of NIDCM with any type of psoriasis after adjusting for the traditional risk factors such as age, sex, race, diabetes mellitus, hypertension, alcohol abuse, cocaine abuse, arrythmias, and obesity
Summary
Psoriasis is a chronic inflammatory skin condition which commonly presents with scaly erythematous plaques. It has a worldwide prevalence ranging from 0.5 to 11% [1]. While the relationship between psoriasis and cardiomyopathies, especially non-ischemic dilated cardiomyopathy (NIDCM), has been suggested through case reports and small observational studies, the association has not been evaluated using a large sample. This population-based study aims to investigate the correlation between patients with psoriasis and non-ischemic dilated cardiomyopathy. Psoriasis is a chronic inflammatory skin condition commonly associated with psoriatic arthritis, malignancy, diabetes, inflammatory bowel disease, and cardiovascular disease. We aim to study the relationship between psoriasis and non-ischemic dilated cardiomyopathy in a large population-based study
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.