Psihometrijske karakteristike srpske verzije Lesterskog upitnika o kašlju kod bolesnika sa sarkoidozome

Branislav Gvozdenović,Nikola Marić,Mira Vuković,Mihailo Stjepanović,Violeta Mihailović-Vučinić,Strahinja Mihailović

doi:10.5937/hpimj1901728g

Branislav Gvozdenović, Nikola Marić + Show 4 more

Open Access

https://doi.org/10.5937/hpimj1901728g

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Abstract

Introduction: Cough is frequent symptom in sarcoidosis and there are no specifi c tools for measurement of its severity in Serbia. Aim: the goal of this study was to translate and validate the Serbian version of the Leices-ter Cough Questionnaire (LCQ) in a population of sarcoidosis patients. Methods: After the LCQ forward-backward translation process, in the cross-sectional study in 275 (180 female) sarcoidosis patients Serbian version of the LCQ was administered together with other standardized instruments for measurement of Patient Reported Outcomes (PROs)-symptoms of dyspnea (assessed by MRC and Borg scales) and fatigue (measured by Fatigue Assessment Scale and List of Daily Activities), and patients' health status (assessed by generic tool-15D). Pulmonary function tests (spirometry and diff using capacity for carbon monoxide) were also measured. Results: Serbian LCQ version showed excellent internal consistency (Cronbach's Alpha of its diff erent scores ranged between 0.901 for physical domain and 0.951 for the total score). Concurent validity assessed by correlations of all LCQ scores with other PROs and pulmonary function tests was very good, since all these correlations were statistically signifi cant. Conclusions: Our results confi rmed that the Serbian version of LCQ is a valid instrument to monitor the infl uence of chronic cough on quality of life in sarcoidosis patients.

Highlights

Sarcoidosis is a chronic multisystem granulomatous disease of unknown origin that is most commonly present in the lungs but may involve any other organ [1].Patients with pulmonary sarcoidosis may have symptoms related directly to the chest such as dyspnea on exertion, chest pain, chest discomfort, cough, and wheeze
A validated Serbian version does not exist, so our aim was to translate and validate Serbian version of the Leicester Cough Questionnaire (LCQ) in sarcoidosis patients in order to provide an instrument for future multinational studies on chronic cough in sarcoidosis patients in particular
This Serbian version of the LCQ was initially administered among ten sarcoidosis patients at the Clinic for Pulmonology, Clinical Center of Serbia in Belgrade, Serbia, in order to assess their understanding of each particular question

Summary

Introduction

Patients with pulmonary sarcoidosis may have symptoms related directly to the chest such as dyspnea on exertion, chest pain, chest discomfort, cough, and wheeze. Patients may develop symptoms related to extrapulmonary organ involvement. Sarcoidosis may cause constitutional symptoms such as fatigue, fever, anorexia, weight loss, generalized weakness, and pain that are not attributable to involvement of any specific organ [2,3]. PROs encompass symptoms and signs of disease, treatment satisfaction and quality of life (QoL) of patients. This is increasingly observed as the regulatory authorities’ requirement due to several limitations of the objective disease outcomes, like pulmonary function tests or radiographic findings. Numerous studies showed that correlations between PROs as subjective outcomes and objective outcomes are rather mild or moderate or even do not exist at all [5]

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