Pseudouridine metabolism. II. Urinary excretion in gout, psoriasis, leukemia, and heterozygous oroticaciduria.

Abstract

Abstract Urinary uric acid and pseudouridine levels were measured in a variety of subjects who had been maintained on a 70 Gm. protein, purine-free diet for 5 to 7 days. In normal subjects pseudouridine and uric acid values were not correlated and pseudouridine excretion values followed a non-Gaussian distribution with a median of 42 mg. per 24 hours. The family of an infant with congenital oroticaciduria excreted normal amounts of pseudouridine. Subjects with leukemia excreted up to 235 mg. of pseudouridine a day, but there was an overlap between the excretion rate of these patients and normal subjects. Patients with gout as a group tended to excrete higher amounts of pseudouridine than normal persons. There was no correlation between urinary uric acid and pseudouridine in these subjects. Psoriatic patients also tended to excrete excessive amounts of pseudouridine. There was a close positive correlation between urinary uric acid, urinary pseudouridine, and percentage skin involvement in these subjects.