Abstract
ENVELOPED RNA viruses from different groups participate readily with each other in phenotypic mixing during maturation at the plasma membrane of host cells. These ‘pseudotypes’ with the envelope antigens of one virus and the genome of the other have been demonstrated for simian virus 5 and vesicular stomatitis virus (VSV)1, for avian or murine RNA tumour viruses and VSV2–4, and for fowl plague virus and VSV5. (An exception has been the lack of interaction between Sindbis virus and VSV6.) We have now found virions containing the RNA genomes of VSV in the envelope antigens of a DNA virus, herpes simplex virus (HSV). These interactions between genomes and antigens of unrelated groups may be part of a mechanism for viral pathogenesis and oncogenesis.
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