Abstract
The alphaherpesvirus pseudorabies virus (PrV) is the causative agent of Aujeszky's disease, an infection of major economic impact in animal husbandry. PrV's natural hosts are porcines but it is able to infect nearly all mammals, excluding humans and other higher primates. In addition to being an important pathogen in livestock, PrV is being used increasingly as a model for elucidating the basic mechanisms of herpesvirus infection in cell culture and in the animal. The first genetically engineered, live virus vaccines to be used on a large scale were derived from PrV. Using a novel approach that has pioneered modern animal disease control, eradication of PrV infection from national pig populations has been achieved using ‘marker’ vaccines that allow serological differentiation between infected and vaccinated animals. On the basis of its distinct neurotropic properties, PrV has also become a major tool in neurobiology for tracing neuronal networks.
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