Abstract
Background: Pseudoporyphyria is an uncommon bullous dermatosis. It shares clinical and histological features with porphyria cutanea tarda, but it occurs in the absence of porphyrin metabolic dysfunction. It is characterized by skin fragility, bullae, milia, and scarring on the dorsum of the hands and other sun-exposed areas. Case: We present a patient on naproxen with recurrent pseudoporyphyria of the dorsal hands associated with the consumption of lemon water. Findings: Biopsy showed a pauci-inflammatory sub epidermal vesicle with caterpillar bodies and laboratory studies lacked any urine or serum porphyrin abnormalities. The cutaneous lesions were noted to resolve with discontinuation of the consumption of lemon water. Keywords: Pseudoporyphyria; Porphyrin; Porphyria Cutanea Tarda; Chlorophyll; Vesicle and Depigmented
Highlights
The cutaneous lesions were noted to resolve with discontinuation of the consumption of lemon water
Pseudoporyphyria is a rare photodermatosis with clinical and histological features similar to those of porphyria cutanea tarda, but lacks the abnormalities seen in porphyrin metabolism [1]
Pseudoporphyria can be differentiated from poryphyria cutanea tarda by the presence of normal porphyrin levels in plasma, erythrocytes, urine, and stool [6]
Summary
Pseudoporyphyria is a rare photodermatosis with clinical and histological features similar to those of porphyria cutanea tarda, but lacks the abnormalities seen in porphyrin metabolism [1]. Findings: Biopsy showed a pauci-inflammatory sub epidermal vesicle with caterpillar bodies and laboratory studies lacked any urine or serum porphyrin abnormalities. This skin photosensitivity disorder has been associated with some known etiological agents. Patient reported being on the medication regimen for several years before the initial blister outbreak.
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