Pseudopapillary and Macrofollicular Microscopic Growth Patterns in an Advanced Stage Ovarian Dysgerminoma: A Case Report

Fatemeh Nili,Niusha Nobari,Alireza Abdollahi

doi:10.30699/ijp.13.1.94

Fatemeh Nili, Niusha Nobari + Show 1 more

Open Access

https://doi.org/10.30699/ijp.13.1.94

Copy DOI

Abstract

Dysgerminoma is one of the two most common types of ovarian germ cell tumors. Providing accurate pathologic diagnosis and treatment planning, the prognosis is good even in advanced stages. Pathologic diagnosis is generally straightforward. In microscopic examination, the usual known growth patterns in tumor cells are solid, trabecular, insular and rarely pseudoglandular. In this paper, we reported an advanced ovarian dysgerminoma with different microscopic patterns of growth, including pseudopapillary and macrofollicular structures, in an 18-year-old woman. The patient underwent staging laparotomy and is currently receiving chemotherapy.

Highlights

The three major types of ovarian tumors are epithelial, sex cord and germ cell [1]
Prognosis is excellent for this group of patients with more than 95% fiveyear survival [7,8,9]
We reported here a case of advanced ovarian dysgerminoma with unusual macroscopic appearance and different patterns of growth in microscopic examination

Summary

Introduction

The three major types of ovarian tumors are epithelial, sex cord and germ cell [1]. Epithelial cell tumors represent the majority of all ovarian neoplasms (82%) [1]. Dysgerminoma is one of two most common types of ovarian germ cell tumor [1,2,3] It has been reported in a wide range of seven months to seventy years, but most cases are young adults and less than twenty years [4]. The Dysgerminomas' response to therapy has turned out to be good [4,5,6] On gross examination, they are usually solid masses with lobulated homogenous cut surface. About 5-15% of patients have bilateral ovarian involvement and few present lymph node metastases and/or peritoneal involvement Prognosis in these groups is well with 85% five-year survival after appropriate chemotherapy [6,10]. Despite the advanced stage of the tumor, peritoneal involvement, surgical complications such as fever, intra-abdominal abscess formation and pleural effusion, the general status of the patient was good in her fourth course of chemotherapy owing to immediate initiation of proper treatment

Discussion

Findings

Conclusion