Abstract
BackgroundMembers of the genus Pseudonocardia have been widely reported and recovered from several ecosystems, such as soil samples and plant samples. Pseudonocardia bacteria colonize the microbial communities on the integument of fungus gardening ant species. We present the first documented case of Pseudonocardia carboxydivorans isolated in human cerebrospinal fluid (CSF). To the best of our knowledge, this is the first report of an human infection by P. carboxydivorans.Case presentationA patient, who suffered a traumatic brain injury a month before, was admitted to this hospital due to gait alteration and cognitive disturbances. Culture of cerebrospinal fluid showed ramified, not acid-fast, Gram positive bacilli. The bacterium was identified by molecular methods as P. carboxydivorans.ConclusionThis is the first documented case of isolating P. carboxydivorans in human CSF in a case of probable meningitis. Further research is needed in order to determine its pathogenic role in human infections.
Highlights
Members of the genus Pseudonocardia have been widely reported and recovered from several ecosystems, such as soil samples and plant samples
Further research is needed in order to determine its pathogenic role in human infections
After 7 days of incubation at 37 °C and 5% CO2, the culture showed growth of white, dry and rough colonies (Fig. 1, Panel a), which were presumably identified as Actinomyces spp. by microbiological routine testing such as the Gram stain (Panel B) and Kinyoun stain (Panel C), showing the presence of ramified, not acidfast, Gram-positive rods..The bacterium was identified by molecular methods of rRNA 16S sequencing,as Pseudonocardia carboxydivorans in the National Center of Microbiology (ISCIII, Madrid, Spain)
Summary
This is the first documented case of isolating P. carboxydivorans in human CSF in a patient with a probable meningitis. Further research is needed in order to determine its pathogenic role in human infections. Availability of data and materials Not applicable. All authors read and approved the final manuscript. Consent for publication Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of written consent is available for review by the Editor of this journal. Ethics approval and consent to participate Not applicable. Author details 1Internal Medicine Department, University General Hospital, C/ Hermanos Falcó s/n, 02006 Albacete, Spain. Author details 1Internal Medicine Department, University General Hospital, C/ Hermanos Falcó s/n, 02006 Albacete, Spain. 2Microbiology Department, University General Hospital, C/Hermanos Falcó s/n, 02006 Albacete, Spain. 3National Center of Microbiology (ISCIII, Madrid), Madrid, Spain
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