Abstract
Background: Pseudomyxoma peritonei is a clinical condition that is characterized as a localized or generalized accumulation of abundant gelatinous material within the abdominal and/or pelvic peritoneal cavity which usually shows a protracted clinical course, long-term prognosis is poor and death ultimately occurs as a consequence of intra-abdominal disease progression. We wanted to emphasize the pathological and clinical features of PMP, ideal treatment of the condition, and the outcome. Data Sources: An extensive Medline search, textbooks, scientific reports and scientific journals are the data sources. We also reviewed reference lists in all articles retrieved in the search as well as those of major texts regarding postsurgical intraperitoneal adhesion formation. Conclusion: The first step to improve the prognosis is to recognize PMP preferably in an early stage. CT imaging should be the choice of radiological assistance in the diagnosis and follow-up. Cytoreductive surgery with intraoperative HIPEC is a treatment strategy with encouraging survival results for selected PMP patients. The pathologic subtype remains the dominant factor for survival. Improvement of survival can be achieved by combination of surgical experience and adequate patient selection. Multiinstutional studies should be recommended. On the other hand, intraperitoneal PDT is potentially an ideal therapy but it needs improvement.
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