Abstract
Background Pseudomyxoma peritonei (PMP) is a rare neoplasm involving the peritoneum. Most PMPs are low-grade appendicular mucinous neoplasms (LAMNs). There have been no reports of PMP originating from a transverse colonic mucinous adenocarcinoma and causing metastatic mucinous adenocarcinoma. Case Presentation. We report a 46-year-old woman who presented with a right abdominal mass of more than 4-month duration. Transverse colonic mucinous adenocarcinoma, PMP, and ovarian metastatic mucinous adenocarcinoma were diagnosed. The patient's diet was normal, and she had no abdominal pain or bloating. The abdomen mass increased in the month before treatment. After chemotherapy, the transverse colon mass and ovarian giant cyst were resected and about 2000 mL of gelatinous tumor tissue was removed. Postoperative histology confirmed PMP from the transverse colonic mucinous adenocarcinoma, ovarian metastatic mucinous adenocarcinoma, and mesocolon metastatic cancer. Multiple lung metastases appeared 8 months after surgery. The patient died 29 months after surgery because of an inability to eat and poor nutrition. A systematic literature review of the management and outcome of all known similar cases is also presented. Conclusions This is the first report of PMP originating from a transverse colonic mucinous adenocarcinoma. It was diagnosed during resective surgery, involved ovarian metastasis, and survival was short. We did an extensive literature review in order to describe the clinical characteristics, histopathological findings, genetic profile, and potential treatments of PMP caused by nonappendiceal mucinous adenocarcinoma.
Highlights
Pseudomyxoma peritonei (PMP) is a rare neoplasm involving the peritoneum
To the best of our knowledge, no cases of PMP induced by transverse colonic mucinous adenocarcinoma with ovarian metastasis have been reported
We present the first case of this rare entity originating from a transverse colonic mucinous adenocarcinoma and causing metastatic mucinous adenocarcinoma
Summary
Pseudomyxoma peritonei (PMP) is a rare neoplasm that involves the peritoneum and has an estimated incidence of one to two cases per million per year [1]. It is characterized by the production of large amounts of mucinous ascites that can fill the peritoneal cavity [2]. To the best of our knowledge, no cases of PMP induced by transverse colonic mucinous adenocarcinoma with ovarian metastasis have been reported. We present the first case of this rare entity originating from a transverse colonic mucinous adenocarcinoma and causing metastatic mucinous adenocarcinoma. A systematic literature review of the management and outcome of all known similar cases is presented
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