Abstract
Multiple isolates of Pseudomonas aeruginosa from individual burn patients were tested for their antibiotic susceptibility-resistance patterns and serotype of their somatic antigen. P. aeruginosa strains with varying antibiograms and/or serotypes were found simultaneously in the same patient. Furthermore, several individual colonies of P. aeruginosa isolated from single-culture sites on patients were found to contain strains differing in antibiogram, serotype, or both. These results suggest that burn patients are co-colonized/co-infected with phenotypically diverse strains of P. aeruginosa. These data may explain in part the failure of single-antibiotic therapy in many patients in whom it has been used to treat severe P. aeruginosa infections.
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