Pseudomonas aeruginosa in Diabetic Foot Infections, Gadarif Diabetic Center, Sudan (2017-2018)

Abstract

Background: The infection of Pseudomonas aeruginosa in Diabetic Foot Infection (DFI), is increasing in Gadarif Diabetic Center, Sudan. Aims: The objective of this study is to report on the frequency, antibiotic sensitivity of P. aeruginosa in patients with diabetic foot infection. Methods: Prospectively, three hundred and fifteen swabs were obtained from diabetic foot infection wound, collected from diabetic foot infection patients who attended Gadarif Diabetic Center during the years (2017-2018). The isolation and identification of P. aeruginosa was done and antimicrobial susceptibility test of commonly used antibiotics (Piperacillin, Ceftazidime, Gentamicin, Ciprofloxacin and Doxycycline) against P. aeruginosa was performed. Results: The present study included 315 bacterial wound swabs, there was 96.30% of bacterial isolates were P. aruginosa. The results of antimicrobial susceptibility test were found to be sensitive to Ciprofloxacin (81.84.4%) and followed by Ceftazidime (78.81.3%), piperacillin (69.71.9%), Gentamicin (66. 68.8%) and Doxycycline (12.12.5%). <p class=MsoNormalCxSpFirst style=margin-bottom:0in;margin-bottom:.0001pt; mso-add-space:auto;text-align:justify;line-height:150%;mso-mirror-indents:yes> Conclusion: The study agrees with previous studies in that, P. aeruginosa was an important causative agents responsible for diabetic foot infections in Gadarif Diabetic Center. Results of the antimicrobial sensitivity of P. aeruginosa isolates against commonly used antibiotics demonstrated the occurrence of resistance to various antipseudomonal agents (Ciproflopxacin, Piperacillin, Ceftazidime and Gentamicin). <p class=MsoNormalCxSpMiddle style=margin-bottom:0in;margin-bottom:.0001pt; mso-add-space:auto;text-align:justify;line-height:150%;mso-mirror-indents:yes> Abbreviations: ATCC: American Type Culture Collection; DFI: Diabetic Foot Infection; GDC: Gadarif Diabetic Centre; MR: Methyl Red; NCCLSs: National Committee for Clinical Laboratory Standards; OF: Oxidative/Fermentative; VP: Voges-Proskauer