Pseudomembranous Candidiasis Indicates High Level Drug Resistance among Patients on Antiretroviral Treatment in Nairobi East District, Kenya

Abstract

Objectives: The aim of this study was to determine antiretroviral drug resistance patterns in Results: Out of (n=45) patients with OPC, (n=28; 62%) had high HIV-RNA levels. The (n=28) patients who mostly presented with pseudomembraneuos candidiasis (n=26; p<.0001), had significantly more previous episodes of OPC (55% versus 18%; P<0.0373) lower median CD4 cell counts (74 versus 521; P<.0001) and higher HIV-RNA median plasma levels (111,191 copies/ml versus <20; P<.0001). The sensitivity (0.96) and specificity (0.87) of pseudomebraneous candidiasis to predict virological failure was high.