Abstract
Pseudomelanosis of the upper gastrointestinal tract is rare and classically associated with oral iron intake, upper gastrointestinal bleeding, diabetes mellitus, end stage renal disease and antihypertensive medication use. Duodenal involvement is well described, but only few cases of combined stomach and duodenal involvement have been reported to date. The lesion is indolent but can mimic more concerning entities like malignant melanoma.
Highlights
Pseudomelanosis in the upper gastrointestinal (GI) tract is infrequently seen
We report an 84-year-old man who presented with lower gastrointestinal bleeding and was found to have areas of blackened gastric and duodenal mucosa on endoscopy, which was confirmed as gastric and duodenal pseudomelanosis on microscopy
We describe one patient with pseudomelanosis of the stomach and duodenum, followed by a brief discussion of this benign entity
Summary
Pseudomelanosis in the upper gastrointestinal (GI) tract is infrequently seen. While it is associated with oral iron intake, upper GI bleeding, diabetes mellitus, renal disease and hypertension, its precise etiology remains elusive. Pseudomelanosis of the upper gastrointestinal tract is rare and classically associated with oral iron intake, upper gastrointestinal bleeding, diabetes mellitus, end stage renal disease and antihypertensive medication use. We report an 84-year-old man who presented with lower gastrointestinal bleeding and was found to have areas of blackened gastric and duodenal mucosa on endoscopy, which was confirmed as gastric and duodenal pseudomelanosis on microscopy. While it is associated with oral iron intake, upper GI bleeding, diabetes mellitus, renal disease and hypertension, its precise etiology remains elusive.
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