Pseudohypoparathyroid tetany

Abstract

Summary 1.A girl, 16 years old, with pseudohypoparathyroidism is reported. 2.Nine patients with this condition have been reported. 3.The distinctive clinical features are: (1) the signs and symptoms of tetany, (2) characteristic alterations in body configuration. The subjects are short and stocky, the facies are rounded, and there are abnormalities in the lengths of the finger bones and often of the bones of the feet, and (3) soft tissue calcifications. 4.The serum calcium is reduced and the inorganic phosphate elevated. 5.The patients fail to respond to parathormone like normal or hypoparathyroid individuals with an increase in the excretion of phosphorus in the urine and an elevation of the serum calcium. 6.Dihydrotachysterol acts more slowly in patients with this disease than in those with true hypoparathyroidism. 7.The treatment of choice is with vitamin D in high doses combined with orally administered calcium. Summary 1.A girl, 16 years old, with pseudohypoparathyroidism is reported. 2.Nine patients with this condition have been reported. 3.The distinctive clinical features are: (1) the signs and symptoms of tetany, (2) characteristic alterations in body configuration. The subjects are short and stocky, the facies are rounded, and there are abnormalities in the lengths of the finger bones and often of the bones of the feet, and (3) soft tissue calcifications. 4.The serum calcium is reduced and the inorganic phosphate elevated. 5.The patients fail to respond to parathormone like normal or hypoparathyroid individuals with an increase in the excretion of phosphorus in the urine and an elevation of the serum calcium. 6.Dihydrotachysterol acts more slowly in patients with this disease than in those with true hypoparathyroidism. 7.The treatment of choice is with vitamin D in high doses combined with orally administered calcium.