Pseudohypogonadism: defective masculinization in a subject with normal FSH, ICSH and testosterone secretion.

Abstract

A 19-year old male is presented with clinical signs of hypoandrogenism but normal excretion of FSH, ICSH and testosterone. In addition, the Clomiphene stimulation test had revealed a normal hormonal reserve. Cariotypes taken from blood and skin ruled out mosaicism as a possible cause. These findings and the absence of response to exogenous testosterone suggested peripheral resistance to androgen. The name "pseudo-hypogonadism" is again suggested for this rare condition in which defective masculinization is at variance with the hormonal studies which are normal.