Pseudoglandular hyperplasia of the conjunctiva: A rare entity

Abstract

Pseudoglandular hyperplasia of the conjunctiva (PHC) is a rare benign epithelial pseudotumor. We report herein a new case of this rare entity, review its histopathological features and discuss its differential diagnoses. The morphologic findings of PHC of the right eye occurring in a 65-year-old man are reported with a review of the related literature. The patient consulted for a swollen conjunctiva mass. MRI revealed a well-limited hypervascular nodule in the right superior palpebral conjunctiva. Surgical excision was performed. On microscopic examination, the specimen was covered with a regular stratified squamous epithelium containing numerous goblet cells. The epithelium showed invagination into the stroma with formation of pseudoglandular structures of various sizes. There was neither nuclear atypia nor mitosis. The diagnosis of PHC was made. PHC is defined as a proliferation of the conjunctival epithelium with prominent glandular structures. Awareness of this entity is crucial to distinguish it from well-differentiated adenosquamous carcinoma to ensure the appropriate treatment.