Abstract
Hepatocellular Carcinoma (HCC) currently remains one of the most lethal malignancies worldwide. Recently, long non-coding RNAs (lncRNAs) had been demonstrated to play a crucial role in the progression of multiple human cancers, including HCC. In this study, we found that lncRNA DUXAP8 was upregulated in tumor samples and served as an oncogene in HCC. Bioinformatics analysis showed that DUXAP8 was significantly associated with the regulation of centrosome organization, homologous recombination, meiotic cell cycle process, sister chromatid segregation, nuclear chromosome segregation, and RNA export from the nucleus. The knockdown of DUXAP8 significantly suppresses cell proliferation and the cell cycle but induces cell apoptosis in HCC. Mechanically, the present study showed that DUXAP8 serves as a sponge of MiR-490-5p to promote the expression of BUB1 in HCC. Although the underlying regulatory mechanisms of DUXAP8 in HCC require further investigation, this study, for the first time, showed that DUXAP8 can serve as a new therapeutic target for HCC.
Highlights
Hepatocellular Carcinoma (HCC) is currently one of the most lethal malignancies worldwide
In order to understand the prognostic value of DUXAP8 in HCC, we performed an integrative analysis of HCC microarray profiles, including GSE84402 and GSE121248 datasets
We observed that DUXAP8 was upregulated in Stage II/III HCC samples compared to Stage I HCC samples (Figure 1D, p < 0.0 and p < 0.005)
Summary
Hepatocellular Carcinoma (HCC) is currently one of the most lethal malignancies worldwide. With the development of RNA-sequencing methods, more than 95% of the human genome had been validated to be non-coding genes, including snoRNAs, microRNAs (miRNAs or miRs), piRNAs, and long non-coding RNAs (lncRNAs). Among these ncRNAs, lncRNAs had been demonstrated to be dysregulated and associated with the progression of HCC. The findings of this study suggest that DUXAP8 could be a novel and suitable predictive biomarker for the risk assessment of recurrence or metastasis of HCC patients but may not be effective in predicting the efficacy of targeted drugs
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
