Abstract
A novel ubiquinone derivative, pseudoalteromone A (1), possessing a 9C nor-monoterpenoid moiety was produced from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium is originally isolated from a cultured-type octocoral Lobophytum crassum. The structure of ubiquinone 1 was established by spectroscopic methods. Pseudoalteromone A (1) exhibited significant cytotoxicity toward the MOLT-4 (human acute lymphoblastic leukemia, IC50=3.764μg/mL) cells and displayed a significant inhibitory effect (inhibition rate 45.1%) on the release of elastase by human neutrophils at a concentration of 10μg/mL.
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